Ganong W F
Chest. 1983 Feb;83(2 Suppl):299-302.
The location and nature of the receptors in the brain on which clonidine acts to decrease renin secretion have been investigated in dogs. Clonidine was injected into the vertebral and carotid arteries, and its effects were compared with those of norepinephrine and epinephrine when injected into the third ventricle. It was also injected intravenously (IV) after transection of the brain stem and following treatment with intraventricular 6-hydroxydopamine. The results suggest that the renin-regulating receptors are located in the brain stem in a region different from the receptors mediating the depressor response, that they are alpha 2-adrenoceptors, and that they are postsynaptic in location. Central alpha 1-adrenoceptors appear to mediate increased renin secretion. Central serotonergic receptors also mediate increased renin secretion, but it is not known how the alpha 1- and alpha 2-adrenoceptors interact with the serotonergic systems.
已经在犬类中研究了可乐定作用于大脑中降低肾素分泌的受体的位置和性质。将可乐定注入椎动脉和颈动脉，并将其效果与注入第三脑室的去甲肾上腺素和肾上腺素的效果进行比较。还在切断脑干后以及经脑室内注射6-羟基多巴胺治疗后静脉注射可乐定。结果表明，调节肾素的受体位于脑干中与介导降压反应的受体不同的区域，它们是α2-肾上腺素能受体，并且它们位于突触后。中枢α1-肾上腺素能受体似乎介导肾素分泌增加。中枢5-羟色胺能受体也介导肾素分泌增加，但尚不清楚α1-和α2-肾上腺素能受体如何与5-羟色胺能系统相互作用。
