甲苯磺丁脲可刺激离体灌注大鼠胃释放胃生长抑素。

Tolbutamide stimulates gastric somatostatin release from isolated perfused rat stomach.

作者信息

Chiba T, Taminato T, Kadowaki S, Chihara K, Matsukura S, Seino Y, Fujita T

出版信息

Diabetes. 1982 Feb;31(2):119-21. doi: 10.2337/diab.31.2.119.

DOI:10.2337/diab.31.2.119

Abstract

The effect of tolbutamide on somatostatin release from the isolated perfused stomach was investigated in both normal and streptozotocin-diabetic rats. Tolbutamide (10, 100, and 1000 microgram/ml) evoked a significant and dose-dependent increase in gastric somatostatin release. The tolbutamide (100 microgram/ml)-induced gastric somatostatin secretion was not influenced by differences in glucose concentration (1.5, 5.5, and 16.5 mM) throughout the perfusion period. Tolbutamide (100 microgram/ml)-induced gastric somatostatin release in streptozotocin-diabetic rats was significantly higher than in normal rats. Thus, tolbutamide is a potent secretagogue for gastric somatostatin secretion, and this effect is more prominent in diabetic animals.

摘要

在正常大鼠和链脲佐菌素诱导的糖尿病大鼠中，研究了甲苯磺丁脲对离体灌注胃中生长抑素释放的影响。甲苯磺丁脲（10、100和1000微克/毫升）引起胃生长抑素释放显著且呈剂量依赖性增加。在整个灌注期间，甲苯磺丁脲（100微克/毫升）诱导的胃生长抑素分泌不受葡萄糖浓度（1.5、5.5和16.5毫摩尔）差异的影响。链脲佐菌素诱导的糖尿病大鼠中，甲苯磺丁脲（100微克/毫升）诱导的胃生长抑素释放显著高于正常大鼠。因此，甲苯磺丁脲是胃生长抑素分泌的有效促分泌剂，且这种作用在糖尿病动物中更为显著。