Trimble E R, Gerber P G, Renold A E
Diabetes. 1982 Feb;31(2):178-81. doi: 10.2337/diab.31.2.178.
Synthetic human pancreatic polypeptide stimulated pancreatic somatostatin secretion by isolated rat islets and by the isolated perfused rat pancreas. In contrast, synthetic bovine pancreatic polypeptide and the C-terminal hexapeptide had no effect on somatostatin secretion. Synthetic human pancreatic polypeptide had only a mild stimulatory effect on glucagon secretion at the highest concentration of the peptide used (2.2 x 10(-6) M0 and in the presence of 16.7 mM glucose.
合成人胰多肽可刺激分离的大鼠胰岛及分离的灌注大鼠胰腺分泌胰腺生长抑素。相比之下，合成牛胰多肽和C末端六肽对生长抑素分泌无影响。在所用多肽的最高浓度（2.2×10⁻⁶ M）且存在16.7 mM葡萄糖的情况下，合成人胰多肽对胰高血糖素分泌仅具有轻微的刺激作用。
