Le Fur G, Zarifian E, Phan T, Cuche H, Flamier A, Bouchami F, Burgevin M C, Loo H, Gérard A, Uzan A
Life Sci. 1983 Jan 17;32(3):249-55. doi: 10.1016/0024-3205(83)90037-1.
[3H]spiroperidol binding to lymphocytes was measured in untreated paranoid or disorganized and treated paranoid schizophrenic patients. An increase in the Bmax was detected in untreated paranoid patients but a decrease was found in the disorganized patients. No difference was detected in the KD value. Neuroleptic treatment produced a decrease in the Bmax without affecting the KD value. Such results did not comply with the down regulation but might be explained by a change in membrane viscosity as [3H]spiroperidol binding sites on lymphocytes were coupled to phospholipid methylation.
在未经治疗的偏执型或紊乱型以及经治疗的偏执型精神分裂症患者中测量了[3H]螺哌啶醇与淋巴细胞的结合情况。在未经治疗的偏执型患者中检测到Bmax增加，但在紊乱型患者中发现Bmax降低。KD值未检测到差异。抗精神病药物治疗使Bmax降低，而不影响KD值。这些结果不符合下调情况，但可能是由于淋巴细胞上的[3H]螺哌啶醇结合位点与磷脂甲基化相关，导致膜粘度发生变化所致。
