[Effect of neuropeptides modulating memory on the background and evoked electrical activity of the cerebral cortex in the rabbit].

The encephalographic correlations of behavioural activity of oligopeptides from the group of memory neuromodulators and similar substances (arginine-vasopressin, a fragment of adrenocorticotropine ACTH4-7 and four its analogues, leu-enkephalin and melanostatine) were studied in rabbits. The encephalogram was activated by these drugs. The fraction of low-frequency components decreased, that of high frequency increased, the amplitude decreased. The effect of ACTH4-7 and vasopressin on the parameters of visual summary evoked potential was dose-dependent. Neuropeptides reduced the latent period and increased the amplitude of summary potentials or depressed these parameters depending on dose. The effects of vasopressin were long-term in nature and lasted for several weeks. The effects of fragments of ACTH and leu-enkephalin lasted for several hours.