Guelfi J F, Braun J P, Benard P, Rico A G, Thouvenot J P
Res Vet Sci. 1982 Nov;33(3):309-12.
In experimental bile obstruction in dogs, the most sensitive change in blood plasma composition is the increase in alkaline phosphatase activity which occurs after eight hours. Maximum alkaline phosphatase activities (approximately 100 times normal values) occur between the fifth and the 14th day. The increase in activity is accompanied by smaller increases in gamma-glutamyl transferase activity, and total bilirubin concentration also increases to a smaller extent and less regularly. Cholestasis also induces an intense cytolysis which is demonstrated mainly by increases in glutamate dehydrogenase and alanine amino transferase activities which are more intense and lasting than those induced by 0.5 ml/kg carbon tetrachloride.
在犬实验性胆汁梗阻中，血浆成分最敏感的变化是碱性磷酸酶活性在8小时后升高。最大碱性磷酸酶活性（约为正常值的100倍）出现在第5天至第14天之间。活性升高的同时，γ-谷氨酰转移酶活性也有较小幅度的升高，总胆红素浓度也有较小幅度且不太规律的升高。胆汁淤积还会引发强烈的细胞溶解，主要表现为谷氨酸脱氢酶和丙氨酸氨基转移酶活性升高，且比0.5毫升/千克四氯化碳诱导的升高更强烈、更持久。
