Bhat A M, Scanlon J W, Lavenstein B, Chuang L, Karoum F
Clin Neuropharmacol. 1982 Dec;5(4):389-94. doi: 10.1097/00002826-198212000-00006.
Twelve-hour urinary excretion of 4-hydroxy-3-methoxymandelic acid (VMA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) was studied in 20 premature infants, 8 without apnea and 12 with apnea. All infants were studied at 1-3 days of postnatal age (before apnea). Nonapneic infants were restudied at 10-15 days of postnatal age. Apneic infants were also restudied 24 h after apnea. Apnea was not associated with decreased urinary excretion of VMA and MHPG. Only HVA, when expressed as microgram/kg body weight, was significantly lower after the onset of apnea. This difference disappeared when HVA was expressed as microgram/mg creatinine. We suggest that apnea of prematurity may not be related to the immaturity of catecholamine pathways.
对20名早产儿进行了研究，测定其12小时尿中4-羟基-3-甲氧基扁桃酸（VMA）、高香草酸（HVA）和3-甲氧基-4-羟基苯乙二醇（MHPG）的排泄量，其中8名无呼吸暂停，12名有呼吸暂停。所有婴儿均在出生后1 - 3天（呼吸暂停前）进行研究。无呼吸暂停的婴儿在出生后10 - 15天再次进行研究。有呼吸暂停的婴儿在呼吸暂停后24小时也再次进行研究。呼吸暂停与VMA和MHPG尿排泄量减少无关。仅HVA以微克/千克体重表示时，呼吸暂停发作后显著降低。当HVA以微克/毫克肌酐表示时，这种差异消失。我们认为早产儿呼吸暂停可能与儿茶酚胺途径不成熟无关。
