典型和非典型抗焦虑药抗冲突效应的差异拮抗作用。

Differential antagonism of the anticonflict effects of typical and atypical anxiolytics.

作者信息

Patel J B, Martin C, Malick J B

出版信息

Eur J Pharmacol. 1982 Dec 24;86(2):295-8. doi: 10.1016/0014-2999(82)90331-4.

Abstract

Selected benzodiazepine and non-benzodiazepine agents were studied alone or in the presence of benzodiazepine antagonists in the shock-induced suppression of drinking (SSD) procedure in rats. The disinhibitory activity of chlordiazepoxide, CL218,872, zopiclone and CGS 9896 was antagonized by two benzodiazepine antagonists, RO-15-1788 and CGS 8216. In contrast, the disinhibitory activity of fenobam, meprobamate, phenobarbital and tracazolate was not antagonized by either RO 15-1788 and CGS 8216. From these data it is apparent that the anticonflict activity of agents that bind to benzodiazepine receptors is blocked by benzodiazepine antagonists. In contrast, the activity of anxiolytics that are not displacers are unaffected even at higher doses.

摘要

在大鼠休克诱导饮水抑制（SSD）实验中，对选定的苯二氮䓬类和非苯二氮䓬类药物单独或在苯二氮䓬类拮抗剂存在的情况下进行了研究。氯氮卓、CL218,872、佐匹克隆和CGS 9896的去抑制活性被两种苯二氮䓬类拮抗剂RO-15-1788和CGS 8216拮抗。相比之下，非诺班、甲丙氨酯、苯巴比妥和曲卡唑酯的去抑制活性未被RO 15-1788和CGS 8216拮抗。从这些数据可以明显看出，与苯二氮䓬受体结合的药物的抗冲突活性被苯二氮䓬类拮抗剂阻断。相比之下，即使在高剂量下，非置换性抗焦虑药的活性也不受影响。