苯二氮䓬受体拮抗剂Ro 15 - 1788对MK - 801抗惊厥和抗冲突作用的影响。
Effect of the benzodiazepine receptor antagonist Ro 15-1788 on the anticonvulsant and anticonflict actions of MK-801.
作者信息
Clineschmidt B V
出版信息
Eur J Pharmacol. 1982 Oct 15;84(1-2):119-21. doi: 10.1016/0014-2999(82)90167-4.
PMID:6814930
Abstract
MK-801, phenobarbital and clonazepam blocked convulsions elicited in mice by bicuculline. Treatment with Ro 15-1788 antagonized the anticonvulsant action of clonazepam, but not MK-801 or phenobarbital. The anticonflict effect in the rat of chlordiazepoxide, but not MK-801, was antagonized by Ro 15-1788. Despite having certain benzodiazepine-like effects in vivo, MK-801 does not act directly or indirectly via receptors for benzodiazepines.
摘要
MK-801、苯巴比妥和氯硝西泮可阻断荷包牡丹碱诱发的小鼠惊厥。用Ro 15-1788处理可拮抗氯硝西泮的抗惊厥作用，但对MK-801或苯巴比妥无此作用。Ro 15-1788可拮抗大鼠中氯氮卓的抗冲突作用，但对MK-801无此作用。尽管MK-801在体内具有某些苯二氮卓样效应，但它并非直接或间接通过苯二氮卓受体起作用。
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