Differential effects of competitive benzodiazepine receptor antagonists on the anticonflict activity of Gö 4962.

The anticonflict activity of the triazolobenzothiadiazine Gö 4962 (40 mg/kg po) in the four-plate test using male NMRI mice was selectively antagonized by beta CCE (10 mg/kg iv), but not by Ro 15-1788 (20 mg/kg ip) or CGS 8216 (20 mg/kg ip), although Gö 4962 has affinity for the benzodiazepine receptor. In contrast, the anticonflict activity of diazepam (4 mg/kg po) was antagonized by all three BZ antagonists. Relative to known putative anxiolytics, this profile of Gö 4962 is unexpected and unique.