Mathur V K, Ramsey E W
J Urol. 1983 Jan;129(1):163-5. doi: 10.1016/s0022-5347(17)51974-6.
Three methods of providing in situ protection to an ischemic kidney were compared in dogs. These were surface cooling using external coils, transvenous hypothermic perfusion and intravenous inosine. The dogs were divided into 3 groups with 20 dogs in each group. Group 1 had the artery occluded for 45 minutes, group 2 for 60 minutes and group 3 for 90 minutes. A further control group of 5 dogs underwent mobilization of the left kidney without ischemia. Contralateral nephrectomy was performed on all animals. The 20 dogs in each group were randomized; 5 undergoing surface cooling, 5 cooling by renal vein perfusion, 5 receiving intravenous inosine and 5 receiving no protection. Function of the solitary kidney was monitored by serum creatinine levels. All 3 methods provided significant protection. Protection provided by surface cooling and inosine was greater than by venous cooling. The protection provided by intravenous inosine was similar to surface cooling for up to 60 minutes but was less at 90 minutes.
在犬类中比较了三种对缺血性肾脏进行原位保护的方法。这些方法包括使用外部线圈进行体表降温、经静脉低温灌注和静脉注射肌苷。将犬分为3组，每组20只。第1组动脉闭塞45分钟，第2组60分钟，第3组90分钟。另外一个由5只犬组成的对照组进行左肾游离但不造成缺血。所有动物均进行对侧肾切除术。每组的20只犬被随机分组；5只接受体表降温，5只通过肾静脉灌注降温，5只接受静脉注射肌苷，5只不接受保护。通过血清肌酐水平监测孤肾的功能。所有三种方法均提供了显著的保护。体表降温和肌苷提供的保护大于静脉降温。静脉注射肌苷提供的保护在60分钟内与体表降温相似，但在90分钟时则较弱。
