转铁蛋白受体表达与非霍奇金淋巴瘤组织学分类及预后的相关性

Correlation of transferrin receptor expression with histological class and outcome in non-Hodgkin lymphoma.

作者信息

Habeshaw J A, Lister T A, Stansfeld A G, Greaves M F

出版信息

Lancet. 1983 Mar 5;1(8323):498-501. doi: 10.1016/s0140-6736(83)92191-8.

Abstract

The proportion of lymphocytes from patients with non-Hodgkin lymphoma (NHL) expressing transferrin receptors in biopsy material from lymph-nodes assayed by binding of the monoclonal antibody OKT9 correlated significantly with the histological class of the tumour. High-grade lymphomas contained 22.5% (range 3-57%) OKT9-positive lymphocytes, and low-grade lymphomas contained 2.5% (range less than 1-22). Since histological class of lymphoma is an important factor in survival, it was expected and confirmed that OKT9 levels were related to survival in these patients. Transferrin receptor is expressed by growing cells. The correlates observed in this series of NHL suggests a relation between transferrin receptor and either the growth fraction, or factors affecting the growth fraction, of the tumour.

摘要

通过单克隆抗体OKT9结合法检测非霍奇金淋巴瘤（NHL）患者淋巴结活检材料中表达转铁蛋白受体的淋巴细胞比例，与肿瘤的组织学类型显著相关。高度恶性淋巴瘤含有22.5%（范围3%-57%）的OKT9阳性淋巴细胞，低度恶性淋巴瘤含有2.5%（范围小于1%-22%）。由于淋巴瘤的组织学类型是生存的一个重要因素，因此可以预期并得到证实，OKT9水平与这些患者的生存相关。转铁蛋白受体由生长中的细胞表达。在这一系列NHL中观察到的相关性表明转铁蛋白受体与肿瘤的生长分数或影响生长分数的因素之间存在关联。