Pileri S, Gobbi M, Rivano M T, Martinelli G
Br J Haematol. 1984 Nov;58(3):501-8. doi: 10.1111/j.1365-2141.1984.tb03997.x.
Lyophilized frozen sections of 24 lymph nodes from patients with different types of non-Hodgkin's malignant lymphoma, diagnosed according to the Kiel Classification, were tested by an immunoperoxidase-ABC-method, in order to assess the expression of the transferrin receptors, recognized by the OKT9 monoclonal antibody. Our results support the hypothesis that OKT9 reactivity of lymphomatous tissues might reflect the histological grading, offering a new important prognostic parameter, and stress the concept that immunological studies in frozen sections allow a more precise definition of the lymphoma phenotype.
对24例根据基尔分类法诊断为不同类型非霍奇金恶性淋巴瘤患者的淋巴结冻干冰冻切片，采用免疫过氧化物酶-抗生物素蛋白-生物素复合物法（ABC法）进行检测，以评估OKT9单克隆抗体识别的转铁蛋白受体的表达。我们的结果支持这样的假说，即淋巴瘤组织的OKT9反应性可能反映组织学分级，提供一个新的重要预后参数，并强调了在冰冻切片中进行免疫学研究可更精确地定义淋巴瘤表型这一概念。
