Powles R L, Morgenstern G R, Kay H E, McElwain T J, Clink H M, Dady P J, Barrett A, Jameson B, Depledge M H, Watson J G, Sloane J, Leigh M, Lumley H, Hedley D, Lawler S D, Filshie J, Robinson B
Lancet. 1983 Mar 19;1(8325):612-5. doi: 10.1016/s0140-6736(83)91793-2.
35 patients were treated for acute myeloid leukaemia or acute lymphoblastic leukaemia with allogeneic bone-marrow grafts from a parent, child, or sibling who was mismatched at the major histocompatibility complex (MHC). 11 of these patients are alive at least 6 months after grafting, 5 of them after more than 2 years. Of the 15 patients aged under 20 at the time of the graft, 8 are alive and well 6 months to 3 years later. Cyclosporin A was given to all patients after grafting. 1 patient died of acute graft-versus-host disease and in 2 other cases this was a major factor in their death. Graft failure caused the death of 2 patients. 4 patients died of recurrent leukaemia. A fatal complication in 12 patients was pulmonary oedema, often associated with convulsions, intravascular haemolysis, and renal failure. Some of these patients had viral or bacterial infections, but in the majority the syndrome was not associated with demonstrable infection. This syndrome, in which the essential lesion appears to be vascular, was much more common in recipients of mismatched than matched grafts. 3 others died from lung disease in which infection was a factor.
35例急性髓细胞白血病或急性淋巴细胞白血病患者接受了来自父母、子女或兄弟姐妹的主要组织相容性复合体（MHC）不匹配的异基因骨髓移植。其中11例患者在移植后至少存活了6个月，5例存活超过2年。在移植时年龄小于20岁的15例患者中，8例在6个月至3年后存活且状况良好。所有患者移植后均给予环孢素A。1例患者死于急性移植物抗宿主病，另外2例中，这是导致他们死亡的主要因素。移植物衰竭导致2例患者死亡。4例患者死于白血病复发。12例患者的致命并发症是肺水肿，常伴有惊厥、血管内溶血和肾衰竭。这些患者中有些有病毒或细菌感染，但大多数情况下，该综合征与可证实的感染无关。这种综合征的基本病变似乎是血管性的，在接受不匹配移植物的受者中比接受匹配移植物的受者中更为常见。另外3例死于肺部疾病，感染是其中一个因素。
