μ阿片异受体：与κ激动剂的区分
Mu opiate isoreceptors: differentiation with kappa agonists.
作者信息
Wood P L, Richard J W, Thakur M
出版信息
Life Sci. 1982;31(20-21):2313-7. doi: 10.1016/0024-3205(82)90145-x.
PMID:6131359
Abstract
In vivo pharmacological data support the concept of mu (mu) isoreceptors in the rat CNS. The mu 1 receptor mediates analgesia and regulation of cholinergic neurons. Naloxazone may be a specific antagonist of this receptor type. In contrast, the mu 2 receptor is responsible for respiratory depression and regulation of nigrostriatal dopaminergic neurons. In this case, the kappa agonists EKC and MR-2034 appear to be specific mu 2 antagonists.
摘要
体内药理学数据支持大鼠中枢神经系统中μ（μ）异受体的概念。μ1受体介导镇痛作用和胆碱能神经元的调节。纳洛沙宗可能是这种受体类型的特异性拮抗剂。相比之下，μ2受体负责呼吸抑制和黑质纹状体多巴胺能神经元的调节。在这种情况下，κ激动剂EKC和MR - 2034似乎是特异性μ2拮抗剂。
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