Ferguson-Segall M, Flynn J J, Walker J, Margules D L
Life Sci. 1982;31(20-21):2233-6. doi: 10.1016/0024-3205(82)90126-6.
Posterior pituitaries of obese mice (ob/ob) contained significantly more immunoreactive dynorphin (P less than .01) and leu-enkephalin (P less than .01) than their lean littermates. Drinking in obese mice was stimulated by 0.3%, and feeding by 10%, of the dose of ethylketocyclazocine, a kappa receptor agonist, needed to produce extra feeding and drinking in lean mice. Obese mice also showed greater and longer lasting suppression of ingestion after MR-2266, a kappa antagonist, than did lean mice. MR-2266 was much more effective than naloxone in suppressing schedule-induced polydipsia in rats. These results indicate that kappa receptors are involved in feeding and drinking and that obesity is associated with changes in these receptors and their ligands.
肥胖小鼠（ob/ob）的垂体后叶中，免疫反应性强啡肽（P<0.01）和亮脑啡肽（P<0.01）的含量明显高于其瘦的同窝小鼠。在瘦小鼠中，能产生额外摄食和饮水行为所需剂量的κ受体激动剂乙基酮环唑辛，0.3%的剂量就能刺激肥胖小鼠饮水，10%的剂量能刺激其摄食。κ受体拮抗剂MR - 2266对肥胖小鼠摄食的抑制作用比瘦小鼠更显著且持续时间更长。在抑制大鼠因定时程序诱导的烦渴方面，MR - 2266比纳洛酮有效得多。这些结果表明，κ受体参与了摄食和饮水过程，且肥胖与这些受体及其配体的变化有关。
