Palkovits M, Epelbaum J, Tapia-Arancibia L, Kordon C
Neuropeptides. 1982 Dec;3(2):139-44. doi: 10.1016/0143-4179(82)90009-9.
Somatostatin (SRIF) concentrations in catecholamine-rich nuclei of the rat brainstem were measured by radioimmunoassay. The study was performed both in control or sham operated animals and after transecting the major projections of hypothalamic SRIF-containing neurons. Concentrations of the peptide were found to be relatively high in the locus coeruleus, the parabrachial nucleus and the nucleus of the solitary tract; they were intermediate in the lateral reticular nucleus (A1 cell group) and low in the substantia nigra. Transection of hypothalamic periventricular efferents resulted in a 58% depletion of SRIF content in the locus coeruleus, while concentrations of the peptide in other areas were unaffected. Transection of the medial forebrain bundle at the level of the lateral hypothalamus decreased SRIF content by 55% in the substantia nigra, but not in the other nuclei tested. It is concluded that the hypothalamus contributes significantly to the somatostatinergic innervation of the locus coeruleus and the substantia nigra, whereas SRIF in the other nuclei is intrinsic or originates outside the hypothalamus.
采用放射免疫分析法测定大鼠脑干富含儿茶酚胺核团中生长抑素（SRIF）的浓度。该研究在对照或假手术动物中进行，并在切断含SRIF的下丘脑神经元的主要投射后进行。发现该肽在蓝斑、臂旁核和孤束核中的浓度相对较高；在外侧网状核（A1细胞群）中浓度中等，在黑质中浓度较低。下丘脑室周传出纤维的横断导致蓝斑中SRIF含量减少58%，而其他区域的肽浓度未受影响。在下丘脑外侧水平切断内侧前脑束使黑质中的SRIF含量减少55%，但在其他测试核团中未减少。结论是，下丘脑对蓝斑和黑质的生长抑素能神经支配有显著贡献，而其他核团中的SRIF是内在的或起源于下丘脑之外。
