抗精神病药物对精神分裂症患者血浆多巴胺-β-羟化酶的影响。
Neuroleptic drug effect on plasma dopamine-beta-hydroxylase in schizophrenia.
作者信息
Baron M, Gruen R, Levitt M, Kane J
出版信息
Neuropsychobiology. 1982;8(6):312-4. doi: 10.1159/000117917.
PMID:6131392
Abstract
Plasma dopamine-beta-hydroxylase (DBH) activity was determined in 8 chronic schizophrenic patients following neuroleptic treatment for 2 months. Enzyme activity was decreased by 13.7 +/- 3.4% (mean +/- SD). The difference from pre-drug levels was not statistically significant. The reduction in DBH activity stabilized after the 1st month of treatment and was unrelated to neuroleptic drug load.
摘要
对8例慢性精神分裂症患者进行了2个月的抗精神病药物治疗后，测定了其血浆多巴胺-β-羟化酶（DBH）活性。酶活性下降了13.7±3.4%（均值±标准差）。与用药前水平的差异无统计学意义。治疗第1个月后，DBH活性的降低趋于稳定，且与抗精神病药物剂量无关。
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