[麦角生物碱治疗应用的药理学基础]
[Pharmacological basis for the therapeutic use of ergot alkaloids].
作者信息
Tran M A, Montastruc J L, Montastruc P
出版信息
Presse Med. 1983 Feb 19;12(8):517-20.
PMID:6131414
Abstract
The main mechanisms of action of ergot alkaloids are discussed. Their clinical use (migraine, uterine haemorrhage, orthostatic hypotension, senile cerebral insufficiency, hyperprolactinaemia or Parkinson's disease) and their adverse effects are explained by an affinity for three kinds of central and peripheral receptors: alpha adrenergic, serotoninergic or dopaminergic receptors.
摘要
本文讨论了麦角生物碱的主要作用机制。通过对三种中枢和外周受体（α肾上腺素能受体、5-羟色胺能受体或多巴胺能受体）的亲和力，解释了它们的临床用途（偏头痛、子宫出血、体位性低血压、老年脑供血不足、高泌乳素血症或帕金森病）及其不良反应。
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