Lataste X
Can J Neurol Sci. 1984 Feb;11(1 Suppl):118-23. doi: 10.1017/s0317167100046266.
The recognition of the dopaminergic properties of some ergot derivatives has initiated new therapeutical approaches in endocrinology as well as in neurology. The pharmacological characterization of the different ergot derivatives during the last decade has largely improved our understanding of central dopaminergic systems. Their development has yielded valuable information on the pharmacology of dopamine receptors involved in the regulatory mechanisms of prolactin secretion and in striatal functions. The clinical application of such new neurobiological concepts has underlined the therapeutical interest of such compounds either in the control of prolactin-dependent endocrine disorders or in the treatment of parkinsonism. Owing to their pharmacological profiles, dopaminergic agonists represent a valuable clinical option especially in the management of Parkinson's disease in view of the problems arising from chronic L-Dopa treatment.
某些麦角衍生物的多巴胺能特性的发现，在内分泌学和神经学领域开创了新的治疗方法。在过去十年中，对不同麦角衍生物的药理学特性进行了深入研究，这极大地增进了我们对中枢多巴胺能系统的理解。它们的研发为参与催乳素分泌调节机制和纹状体功能的多巴胺受体药理学提供了有价值的信息。这些新的神经生物学概念的临床应用凸显了此类化合物在控制催乳素依赖性内分泌疾病或治疗帕金森病方面的治疗价值。鉴于长期使用左旋多巴治疗引发的问题，多巴胺能激动剂因其药理学特性，成为一种有价值的临床选择，尤其在帕金森病的治疗中。
