Dunwiddie T V, Roberson N L, Worth T
Pharmacol Biochem Behav. 1982 Dec;17(6):1257-64. doi: 10.1016/0091-3057(82)90130-7.
A variety of drugs which either mimic or antagonize the effects of norepinephrine and dopamine were tested for their ability to modulate long-term potentiation (LTP) in the rat hippocampus in vitro. Neither administration of norepinephrine, amphetamine or adrenergic antagonists, nor pretreatment with reserpine or DSP4 (which selectively destroys noradrenergic afferents to the hippocampus) had any significant effect on the magnitude of LTP. Isoproterenol, a beta-adrenergic receptor agonist, was able to partially block LTP, but this did not appear to be due to a direct action of isoproterenol on LTP. Neuroleptic drugs such as trifluoperazine were able to block LTP almost completely; however, this action was not stereospecific. Other dopamine antagonists such as sulpiride had no effect on LTP. The ability of neuroleptics to antagonize LTP was more closely related to their ability to block calmodulin than to their relative potencies as dopamine antagonists. It would appear that neither norepinephrine nor adrenergic antagonists influence the amount of LTP elicited by repetitive stimulation; however, drugs which have been shown to interfere with calmodulin-mediated cellular processes do antagonize this phenomenon.
测试了多种模拟或拮抗去甲肾上腺素和多巴胺作用的药物在体外调节大鼠海马体中长时程增强（LTP）的能力。给予去甲肾上腺素、苯丙胺或肾上腺素能拮抗剂，以及用利血平或DSP4（选择性破坏海马体去甲肾上腺素能传入神经）进行预处理，均对LTP的幅度没有显著影响。β-肾上腺素能受体激动剂异丙肾上腺素能够部分阻断LTP，但这似乎并非异丙肾上腺素对LTP的直接作用所致。氟奋乃静等抗精神病药物能够几乎完全阻断LTP；然而，这种作用不具有立体特异性。其他多巴胺拮抗剂如舒必利对LTP没有影响。抗精神病药物拮抗LTP的能力与其阻断钙调蛋白的能力比与其作为多巴胺拮抗剂的相对效力更密切相关。似乎去甲肾上腺素和肾上腺素能拮抗剂均不影响重复刺激引发的LTP量；然而，已证明干扰钙调蛋白介导的细胞过程的药物确实会拮抗这一现象。
