Delanoy R L, Tucci D L, Gold P E
Pharmacol Biochem Behav. 1983 Jan;18(1):137-9. doi: 10.1016/0091-3057(83)90263-0.
Long term potentiation (LTP) has received considerable attention as a neurophysiological analog of memory. Amphetamine, as well as several other catecholamine agonists, can enhance behaviorally-assessed memory storage in a variety of training situations. The present experiments tested the effects of amphetamine on LTP produced by high frequency stimulation of the perforant path in rats. The results indicate that amphetamine can enhance the development of LTP under some but not all testing procedures. Studies of the neurobiological bases by which central and peripheral catecholamines modulate memory storage may be augmented by examinations of catecholamine effects on a specific form of long-lasting change in brain function. Similarly, the ability to manipulate LTP may prove to be an important aid in examinations of neurobiological correlates of this phenomenon.
长期增强作用（LTP）作为记忆的神经生理学类似物已受到广泛关注。安非他明以及其他几种儿茶酚胺激动剂，在各种训练情境下都能增强行为评估的记忆存储。本实验测试了安非他明对大鼠高频刺激穿通通路所产生的LTP的影响。结果表明，在某些但并非所有测试程序下，安非他明可增强LTP的发展。通过研究儿茶酚胺对大脑功能特定形式的长期变化的影响，可能会加强对中枢和外周儿茶酚胺调节记忆存储的神经生物学基础的研究。同样，操纵LTP的能力可能被证明是研究这一现象的神经生物学相关性的重要辅助手段。
