精神药物的药代动力学：它能告诉我们什么？

Pharmacokinetics of psychotropic drugs: what can it tell us?

Hrdina P D, Hutchinson L J, Lapierre Y D, Perel J M, Reed K L

Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(4-6):681-8. doi: 10.1016/s0278-5846(82)80169-3.

Abstract

Knowledge of basic pharmacokinetic parameters may help the clinician to optimize drug treatment regimen. 2. For some psychotropic drugs (e.g. lithium and some antidepressants) a good correlation exists between plasma levels and therapeutic or toxic effects. 3. "Optimum" steady state levels can now be predicted from single dose blood level data of some drugs (lithium, nortriptyline, desipramine). 4. Altered pharmacokinetics in elderly and children have to be taken into consideration in treatment with psychotropic drugs. 5. With development of suitable drug assays, plasma level control of therapy is becoming a part of a good clinical practice.

摘要

了解基本的药代动力学参数可能有助于临床医生优化药物治疗方案。2. 对于某些精神药物（如锂盐和一些抗抑郁药），血浆水平与治疗效果或毒性作用之间存在良好的相关性。3. 现在可以根据某些药物（锂盐、去甲替林、地昔帕明）的单剂量血药水平数据预测“最佳”稳态水平。4. 在使用精神药物治疗时，必须考虑老年人和儿童药代动力学的改变。5. 随着合适的药物检测方法的发展，血浆水平治疗监测正成为良好临床实践的一部分。