大鼠乳腺中硫醚氨酸生成酶
Enzymes of mercapturic acid production in rat mammary gland.
作者信息
Puente J, Castellon E, Sapag-Hagar M
出版信息
Biochem J. 1982 Dec 1;207(3):605-8. doi: 10.1042/bj2070605.
Abstract
- The enzymes glutathione S-transferase, gamma-glutamyl peptidyltransferase and dipeptidase, which participate in the detoxification pathway through mercapturic acid production, were measured in rat mammary gland during pregnancy and lactation. 2. Mammary-gland concentration of reduced glutathione showed, concomitantly with the enzyme activities, a significant increase during lactation. 3. The mammary-gland glutathione S-transferase exhibits characteristics quite similar to those described for the liver and kidney enzymes with respect to substrates, isoenzymes, molecular weight and probenecid and bilirubin inhibition. 4. In view of these similarities, mammary-gland glutathione S-transferase may play the same role as a cytoplasmic organic-anion receptor proposed for the hepatic enzyme. It may also represent a detoxification pathway for protecting the mammary tissue during the lactogenic cycle.
摘要
- 在大鼠孕期和哺乳期，对参与通过硫醚氨酸生成进行解毒途径的谷胱甘肽S-转移酶、γ-谷氨酰肽基转移酶和二肽酶进行了测定。2. 还原型谷胱甘肽的乳腺浓度与酶活性同步，在哺乳期显著增加。3. 乳腺谷胱甘肽S-转移酶在底物、同工酶、分子量以及丙磺舒和胆红素抑制方面表现出与肝脏和肾脏酶非常相似的特征。4. 鉴于这些相似性，乳腺谷胱甘肽S-转移酶可能发挥与肝脏酶所提出的细胞质有机阴离子受体相同的作用。它也可能代表一种在泌乳周期中保护乳腺组织的解毒途径。
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