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[含有苯海拉明、N,N-二乙基间甲苯酰胺和邻苯二甲酸二甲酯成分的水凝胶的抗组胺作用]

[Antihistaminic effect of a hydrogel with the components diphenhydramine, N,N-diethyl-m-toluamide and phthalic acid dimethyl ester].

作者信息

Oelschläger H, Rothley D

出版信息

Arzneimittelforschung. 1983;33(1):169-72.

PMID:6131676
Abstract

The combination of the antihistamine diphenhydramine as well as the repellents N,N-diethyl-m-toluamide and dimethylphthalate as the active constituents of an insect repellent (Pellit) guarantees a remarkable antihistaminic effect. Surprisingly the repellent N,N-diethyl-m-toluamide proved itself to be an antihistamine. The UV-erythema model was used on the dorsal skin of male volunteers.

摘要

抗组胺药苯海拉明与驱虫剂N,N-二乙基间甲苯甲酰胺和邻苯二甲酸二甲酯的组合作为一种驱虫剂(Pellit)的活性成分,保证了显著的抗组胺作用。令人惊讶的是,驱虫剂N,N-二乙基间甲苯甲酰胺被证明本身就是一种抗组胺药。在男性志愿者的背部皮肤使用紫外线红斑模型。

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