Kales A, Soldatos C R, Bixler E O, Goff P J, Vela-Bueno A
Pharmacology. 1983;26(3):138-49. doi: 10.1159/000137795.
Midazolam, an investigational hypnotic, was evaluated for effectiveness, side effects, and withdrawal phenomena in doses of 10, 20, and 30 mg in three separate sleep laboratory studies, each including 4 placebo-baseline nights, 7 drug nights, and 3 placebo-withdrawal nights. Only a slight to moderate degree of effectiveness was shown across the three doses; this effectiveness was much more pronounced during the first third of the night. There was no dose-response effect for effectiveness with either initial or continued drug administration. In general, there was less effectiveness on the last 3 drug nights, indicating a potential for the development of tolerance over a relatively short period of time. Following withdrawal there was a marked dose-related worsening of sleep above baseline levels (rebound insomnia).
咪达唑仑是一种研究中的催眠药，在三项独立的睡眠实验室研究中，分别以10毫克、20毫克和30毫克的剂量评估了其有效性、副作用和撤药现象。每项研究包括4个安慰剂基线夜晚、7个用药夜晚和3个安慰剂撤药夜晚。在这三种剂量下均显示出轻微至中度的有效性；这种有效性在夜间的前三分之一时间更为明显。无论是初始用药还是持续用药，有效性均无剂量反应效应。总体而言，在最后3个用药夜晚有效性较低，表明在相对较短的时间内有产生耐受性的可能。撤药后，睡眠比基线水平有明显的剂量相关恶化（反弹性失眠）。
