Vgontzas A N, Kales A, Bixler E O, Myers D C
Sleep Research and Treatment Center, Hershey, Pennsylvania.
Eur J Clin Pharmacol. 1994;46(3):209-13. doi: 10.1007/BF00192550.
Temazepam, 7.5 mg was evaluated in the sleep laboratory in 8 elderly insomniacs, using a 14-night protocol (4 placebo-baseline nights, 7 drug nights, and 3 placebo-withdrawal nights). With short-term use temazepam was found to be effective, producing a significant improvement in total wake time from baseline (100 vs. 145 min). With continued drug administration, total wake time remained below baseline but not significantly so (125 vs. 145 min). During drug administration, there were no major CNS and behavioral adverse effects reported such as daytime sedation, memory impairment or hyperexcitability (daytime anxiety). Following drug withdrawal, there was no significant increase in wakefulness, i.e., no rebound insomnia (150 vs. 145 min). In summary, temazepam, 7.5 mg is effective in elderly subjects with short-term use and has a minimum of adverse effects. Use of hypnotic drugs is an adjunctive therapy which should be for a short-term period with subsequent short-term intermittent use as needed. Because of its low propensity for producing rebound insomnia, temazepam can be effectively used in this manner.
对8名老年失眠患者在睡眠实验室中评估了7.5毫克替马西泮，采用14晚方案（4个安慰剂基线夜、7个用药夜和3个安慰剂撤药夜）。发现短期使用替马西泮有效，与基线相比总觉醒时间有显著改善（100分钟对145分钟）。持续给药时，总觉醒时间仍低于基线，但差异不显著（125分钟对145分钟）。给药期间，未报告有重大的中枢神经系统和行为不良反应，如日间镇静、记忆损害或过度兴奋（日间焦虑）。撤药后，觉醒没有显著增加，即没有反弹性失眠（150分钟对145分钟）。总之，7.5毫克替马西泮对老年患者短期使用有效，且不良反应最小。催眠药物的使用是一种辅助治疗，应短期使用，随后根据需要短期间歇使用。由于其产生反弹性失眠的倾向较低，替马西泮可以以这种方式有效使用。
