Norlander A, Norman A, Samuelson K, Sundblad R
Acta Chir Scand. 1983;149(1):83-8.
Non-sulphated conjugates of cholic (C) and chenodeoxycholic (CDC) acids in serum and total conjugates in urine were determined by radioimmunoassay during drainage of extrahepatic cholestasis in twelve patients studied under three different situations: without refeeding of bile, with refeeding after a delay of one to eight days, and with immediate refeeding. The changes in the serum concentrations and renal excretion of C and CDC varied considerably between patients, but the following general features could be discerned: In patients without bile refeeding but with external drainage, the serum concentrations and renal excretion of C and CDC decreased rapidly. In patients with delayed bile refeeding during drainage, the serum concentrations of C and CDC increased when refeeding of bile was begun but only slightly and temporarily, and no influence on renal excretion could be observed. In patients with immediate bile refeeding through an internal drainage the serum concentrations decreased slowly and renal excretion increased during the first week. These differences in the pattern of serum bile acid concentrations were not reflected in the serum concentrations of bilirubin, alkaline phosphatase, alanine aminotransferase or gamma glutamyltransferase.
在12例患者肝外胆汁淤积引流期间，通过放射免疫分析法测定了血清中胆酸（C）和鹅去氧胆酸（CDC）的非硫酸化结合物以及尿液中的总结合物，这些患者在三种不同情况下接受研究：不进行胆汁回输、延迟1至8天后进行回输以及立即进行回输。患者之间C和CDC的血清浓度及肾排泄变化差异很大，但可看出以下一般特征：在不进行胆汁回输但有外部引流的患者中，C和CDC的血清浓度及肾排泄迅速下降。在引流期间延迟胆汁回输的患者中，开始胆汁回输时C和CDC的血清浓度升高，但仅轻微且短暂，且未观察到对肾排泄有影响。在通过内部引流立即进行胆汁回输的患者中，血清浓度在第一周缓慢下降，肾排泄增加。血清胆汁酸浓度模式的这些差异在胆红素、碱性磷酸酶、丙氨酸转氨酶或γ-谷氨酰转移酶的血清浓度中未得到体现。
