Morrison J H, Benoit R, Magistretti P J, Bloom F E
Brain Res. 1983 Mar 7;262(2):344-51. doi: 10.1016/0006-8993(83)91031-4.
Mammalian brain contains 3 peptides related to the pro-somatostatin molecule: somatostatin-14 (SS14), the form originally identified from hypothalamic extracts, somatostatin-28 (SS28) and somatostatin 28 (1-12) (SS28 (1-12)). By using antibodies which selectively recognize one or more of these 3 somatostatin-related peptides, we have characterized their immunohistochemical distribution in neocortex. These somatostatin-related peptides have a specific laminar distribution in cortex and are differentially distributed such that SS28 is largely restricted to cell bodies, whereas SS28 (1-12) is preferentially localized in neuronal processes and terminals in a density which far exceeds that revealed by SS-14 immunoreactivity. These data suggest that there may be an intraneuronal transformation from a SS28-like peptide to a SS28 (1-12)-like peptide. In addition, the enriched distribution of nerve fibers containing the antigenic determinant, SS28 (1-12), strongly implies that somatostatin-related peptides constitute a major neurotransmitter system in neocortex. The morphological characteristics of this system are homologous with long projection pathways such as the cortico-cortical specific intrinsic systems as well as projections.
哺乳动物的大脑含有3种与促生长抑素分子相关的肽：生长抑素-14（SS14），最初从下丘脑提取物中鉴定出的形式；生长抑素-28（SS28）和生长抑素28（1-12）（SS28（1-12））。通过使用能选择性识别这3种与生长抑素相关肽中的一种或多种的抗体，我们已对它们在新皮层中的免疫组织化学分布进行了表征。这些与生长抑素相关的肽在皮层中具有特定的分层分布，且分布存在差异，使得SS28主要局限于细胞体，而SS28（1-12）优先定位于神经元突起和终末，其密度远远超过生长抑素-14免疫反应性所显示的密度。这些数据表明，可能存在从类似SS28的肽到类似SS28（1-12）的肽的神经元内转化。此外，含有抗原决定簇SS28（1-12）的神经纤维的丰富分布强烈暗示与生长抑素相关的肽构成新皮层中的一个主要神经递质系统。该系统的形态学特征与诸如皮质-皮质特异性内在系统以及投射等长投射通路同源。
