药物对沙鼠脑内乙酰胆碱水平的影响。

Effect of drugs on brain acetylcholine level in Gerbillus pyramidum.

Fathi M M

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;74(1):15-21. doi: 10.1016/0742-8413(83)90140-8.

Abstract

The quantitative estimation of total acetylcholine content in the whole brain tissue in normal Egyptian gerbil Gerbillus pyramidum, gives an average of 1.43 +/- 0.06 micrograms of acetylcholine chloride/g fresh brain tissue. 2. The brain acetylcholine level in Gerbillus pyramidum was generally found to vary with the changes induced in the brain activity by drugs. 3. Depressants caused a increase and convulsants a decrease in total brain acetylcholine level. 4. Phenytoin depressed the brain activity but lowered brain acetylcholine level.

摘要

对正常埃及沙鼠（长爪沙鼠）全脑组织中总乙酰胆碱含量进行定量估算，得出平均每克新鲜脑组织中含有1.43±0.06微克氯化乙酰胆碱。2. 一般发现，长爪沙鼠的脑乙酰胆碱水平会随着药物引起的脑活动变化而改变。3. 抑制剂会使脑总乙酰胆碱水平升高，而惊厥剂则会使其降低。4. 苯妥英抑制脑活动，但会降低脑乙酰胆碱水平。