Fathi M M, Asaad A M
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(2):467-74. doi: 10.1016/0742-8413(85)90194-x.
The effect of reserpine and meprobamate on the total acetylcholine content and acetylcholinesterase activity in the brain tissue of the kusu rat, Arvicanthis niloticus, was studied. The total acetylcholine content and acetylcholinesterase activity were determined 1 hr after i.p. injection of different doses of reserpine (0.25, 0.5 and 1 mg/ml/100 g body wt) and meprobamate (6.25, 12.5 and 25 mg/ml/100 g body wt). The effect of different time intervals (1, 10, 30 min, 1, 2.5, 5, 8, 12, 24 and 48 hr) on the total acetylcholine content and acetylcholinesterase activity was investigated after i.p. injection of 0.5 mg of reserpine and 12.5 mg of meprobamate/ml/100 g body wt. Both reserpine and meprobamate caused an increase in the total ACh content in the brain tissue of Arvicanthis niloticus which was suggested to be due to a decrease in the release of ACh, since both reserpine and meprobamate inhibited AChE activity after some tested periods. The effect of meprobamate was observed to be stronger than that of reserpine.
研究了利血平和眠尔通对尼罗多齿巨鼠脑组织中总乙酰胆碱含量和乙酰胆碱酯酶活性的影响。腹腔注射不同剂量的利血平（0.25、0.5和1毫克/毫升/100克体重）和眠尔通（6.25、12.5和25毫克/毫升/100克体重）1小时后，测定总乙酰胆碱含量和乙酰胆碱酯酶活性。腹腔注射0.5毫克利血平和12.5毫克眠尔通/毫升/100克体重后，研究了不同时间间隔（1、10、30分钟，1、2.5、5、8、12、24和48小时）对总乙酰胆碱含量和乙酰胆碱酯酶活性的影响。利血平和眠尔通均导致尼罗多齿巨鼠脑组织中总乙酰胆碱含量增加，这被认为是由于乙酰胆碱释放减少所致，因为在一些测试时间段后，利血平和眠尔通均抑制了乙酰胆碱酯酶活性。观察到眠尔通的作用比利血平更强。
