曲唑酮的代谢产物间氯苯哌嗪对曲唑酮抑制回避行为作用的逆转。 - Suppr | 超能文献

Reversal of depressant action of trazodone on avoidance behaviour by its metabolite m-chlorophenylpiperazine.

作者信息

Sansone M, Melzacka M, Hano J, Vetulani J

出版信息

J Pharm Pharmacol. 1983 Mar;35(3):189-90. doi: 10.1111/j.2042-7158.1983.tb04307.x.

DOI:10.1111/j.2042-7158.1983.tb04307.x

Abstract

摘要

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Reversal of depressant action of trazodone on avoidance behaviour by its metabolite m-chlorophenylpiperazine.曲唑酮的代谢产物间氯苯哌嗪对曲唑酮抑制回避行为作用的逆转。

J Pharm Pharmacol. 1983 Mar;35(3):189-90. doi: 10.1111/j.2042-7158.1983.tb04307.x.

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The role of trazodone metabolism in its inhibitory action on avoidance response.

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Opposite action of m-chlorophenylpiperazine on avoidance depression induced by trazodone and pimozide in CD-1 mice.间氯苯哌嗪对CD-1小鼠中曲唑酮和匹莫齐特诱导的回避性抑郁的相反作用。

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J Pharm Pharmacol. 1985 Jul;37(7):504-6. doi: 10.1111/j.2042-7158.1985.tb03053.x.

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Blockade of conditioned avoidance responding by trazodone, etoperidone, and MCPP.曲唑酮、依托哌酮和间氯苯哌嗪对条件性回避反应的阻断作用。

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The effect of chronic administration of trazodone on the acquisition of avoidance behavior in mice.慢性给予曲唑酮对小鼠回避行为习得的影响。

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Effect of dosage and route of administration of trazodone on cerebral concentration of 1-m-chlorophenylpiperazine in rats. Kinetics of trazodone biotransformation in rats.曲唑酮的剂量和给药途径对大鼠脑中1-间氯苯基哌嗪浓度的影响。大鼠曲唑酮生物转化的动力学。

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Blockade by trazodone of naloxone-precipitated jumping on morphine-dependent rats: correlation with brain levels of m-chlorophenylpiperazine.曲唑酮对纳洛酮诱发的吗啡依赖大鼠跳跃反应的阻断作用：与间氯苯哌嗪脑内水平的相关性

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1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole.1-间氯苯基哌嗪是精神药物曲唑酮、乙哌立酮和米哌唑共同的活性代谢物。

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Antidepressant-like effects of trazodone on a behavioral screen are mediated by trazodone, not the metabolite m-chlorophenylpiperazine.曲唑酮在行为筛选中的抗抑郁样作用是由曲唑酮介导的，而非其代谢产物间氯苯哌嗪。

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引用本文的文献

1

Opposite action of m-chlorophenylpiperazine on avoidance depression induced by trazodone and pimozide in CD-1 mice.间氯苯哌嗪对CD-1小鼠中曲唑酮和匹莫齐特诱导的回避性抑郁的相反作用。

Psychopharmacology (Berl). 1984;83(2):166-8. doi: 10.1007/BF00429728.