曲唑酮及其代谢产物间氯苯哌嗪延长硫喷妥钠诱导的睡眠时间。
Prolongation of thiopentone-induced sleep by trazodone and its metabolite, m-chlorophenylpiperazine.
作者信息
Adamus A, Sansone M, Melzacka M, Vetulani J
出版信息
J Pharm Pharmacol. 1985 Jul;37(7):504-6. doi: 10.1111/j.2042-7158.1985.tb03053.x.
Abstract
Trazodone and its metabolite, m-chlorophenylpiperazine (CPP) prolonged significantly thiopentone-induced sleep in mice. Neither trazodone, nor CPP changed the cerebral concentrations of thiopentone. As cyproheptadine by itself did not affect thiopentone sleep and did not antagonize the effect of CPP, the effect of trazodone and CPP seems to be independent of their respective 5-HT-antagonistic and 5-HT-agonistic properties.
摘要
曲唑酮及其代谢产物间氯苯哌嗪（CPP）可显著延长硫喷妥钠诱导的小鼠睡眠时间。曲唑酮和CPP均未改变硫喷妥钠的脑内浓度。由于赛庚啶本身不影响硫喷妥钠诱导的睡眠，也不拮抗CPP的作用，因此曲唑酮和CPP的作用似乎与其各自的5-羟色胺拮抗和5-羟色胺激动特性无关。
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