Khomaziuk A I, Iakusheva L F, Iavorskiĭ L A, Neshcheret A P
Kardiologiia. 1983 Feb;23(2):104-9.
An experimental study in dogs with intact thoracic cavity under morphine-chloralose narcosis featured coronary catheterization, extracorporeal perfusion and resistography as well as catheterization of the heart cavities and the coronary sinus. Hemodynamic and respiratory parameters were recorded simultaneously. PO2, PCO2 and pH were measured in the inflowing and outflowing blood. The effect of insulin on circulatory response in acute hypoxic hypoxia was examined before and after obsidan block of beta-adrenoreactive systems. Insulin administered after the obsidan beta-adrenergic block was found to limit coronary dilatation and reduce myocardial oxygen consumption in a more pronounced measure. It is suggested that the effect of insulin on coronary dilatation is due to reduced myocardial oxygen consumption resulting from its action on the heart's beta-adrenergic systems.
在吗啡-氯醛糖麻醉下对胸腔完整的犬进行的一项实验研究，其特点包括冠状动脉插管、体外灌注和电阻抗描记法，以及心腔和冠状窦插管。同时记录血流动力学和呼吸参数。测量流入和流出血液中的PO2、PCO2和pH。在使用奥昔丹阻断β-肾上腺素能系统前后，研究了胰岛素对急性低张性缺氧时循环反应的影响。发现在奥昔丹β-肾上腺素能阻断后给予胰岛素，能更显著地限制冠状动脉扩张并降低心肌耗氧量。提示胰岛素对冠状动脉扩张的作用是由于其作用于心脏的β-肾上腺素能系统导致心肌耗氧量降低所致。
