Kipshidze N N, Neshcheret A P, Khomaziuk A I
Kardiologiia. 1982 Oct;22(10):60-5.
The effect of dopamine on coronary and systemic circulation was examined in an experimental study on dogs using catheterization and extracorporeal perfusion of the bypassing branch of the left coronary artery, and simultaneous recording of heart's vascular resistance as well as cardio- and hemodynamic patterns. Dopamine introduced into coronary perfusion flow caused a dilatation of coronary vessels, a reflex drop in arterial blood pressure and peripheral vascular resistance, and changes in heart rate and intensity of cardiac contractions. Dopamine dosage should be about ten times as high to reproduce cardiodynamic and hemodynamic effects, comparable with the response to adrenaline and noradrenaline in terms of magnitude and pattern of development. Coronary vessels are dilated in two steps, through cholinergic activation and direct stimulation of beta-adrenoreactive systems. These two phases can be blocked by atropine and obsidan, respectively. After m-cholinergic and beta-adrenoreactive systems are blocked, dopamine produces a slight coronary vasoconstriction.
在一项对狗的实验研究中，通过导管插入术和左冠状动脉旁路分支的体外灌注，并同时记录心脏血管阻力以及心脏和血流动力学模式，研究了多巴胺对冠状动脉和体循环的影响。注入冠状动脉灌注流中的多巴胺会导致冠状动脉血管扩张、动脉血压和外周血管阻力反射性下降，以及心率和心脏收缩强度的变化。要重现与肾上腺素和去甲肾上腺素在强度和发展模式方面相当的心脏动力学和血流动力学效应，多巴胺的剂量应高出约十倍。冠状动脉血管通过胆碱能激活和对β-肾上腺素能系统的直接刺激分两步扩张。这两个阶段可分别被阿托品和心得安阻断。在M-胆碱能和β-肾上腺素能系统被阻断后，多巴胺会产生轻微的冠状动脉血管收缩。
