三唑仑与硝西泮及奥沙西泮治疗失眠的比较：两项双盲、交叉研究的序贯分析
Triazolam compared with nitrazepam and with oxazepam in insomnia: two double-blind, crossover studies analyzed sequentially.
作者信息
Dordain G, Puech A J, Simon P
出版信息
Br J Clin Pharmacol. 1981;11 Suppl 1(Suppl 1):43S-49S. doi: 10.1111/j.1365-2125.1981.tb01838.x.
Abstract
1 In two double-blind, crossover studies, general practitioners compared the hypnotic activity of triazolam 0.50 mg with that of nitrazepam 5 mg or oxazepam 50 mg in outpatient insomnias. 2 The patient's preferences served as the main criterion, and were processed by sequential analysis. 3 More patients (P less than 0.05) preferred triazolam to nitrazepam (triazolam 28; nitrazepam 11; no preference 9). 4 The numbers of patients who preferred triazolam or oxazepam did not differ significantly. 5 Triazolam and oxazepam affected sleep parameters similarly except for onset of sleep and feeling in the morning, for which triazolam seemed to be superior to oxazepam.
摘要
- 在两项双盲交叉研究中，全科医生比较了0.50毫克三唑仑与5毫克硝西泮或50毫克奥沙西泮在门诊失眠患者中的催眠活性。2. 以患者的偏好作为主要标准，并通过序贯分析进行处理。3. 更多患者（P<0.05）更喜欢三唑仑而非硝西泮（三唑仑组28例；硝西泮组11例；无偏好9例）。4. 更喜欢三唑仑或奥沙西泮的患者人数无显著差异。5. 三唑仑和奥沙西泮对睡眠参数的影响相似，但在入睡和早晨的感觉方面，三唑仑似乎优于奥沙西泮。
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Triazolam compared with nitrazepam and with oxazepam in insomnia: two double-blind, crossover studies analyzed sequentially.三唑仑与硝西泮及奥沙西泮治疗失眠的比较：两项双盲、交叉研究的序贯分析
Br J Clin Pharmacol. 1981;11 Suppl 1(Suppl 1):43S-49S. doi: 10.1111/j.1365-2125.1981.tb01838.x.
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本文引用的文献
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2
[A double-blind crossover study by general practitioners comparing triazolam and nitrazepam in insomniacs].
Therapie. 1978 May-Jun;33(3):287-92.
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Disposition of triazolam, 8-chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a]benzodiazepine, in the dog.
Drug Metab Dispos. 1977 Nov-Dec;5(6):547-55.
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Preference studies of triazolam with standard hypnotics in out-patients with insomnia.三唑仑与标准催眠药用于门诊失眠患者的偏好性研究。
J Int Med Res. 1976;4(4):247-54. doi: 10.1177/030006057600400407.
5
A comparison of the effects of flurazepam 30 mg and triazolam 0.5 mg on the sleep of insomniacs.30毫克氟西泮与0.5毫克三唑仑对失眠症患者睡眠影响的比较。
Psychopharmacology (Berl). 1976 May 5;47(1):81-6. doi: 10.1007/BF00428706.
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