苯二氮䓬类药物会损害平稳跟踪眼球运动。
Benzodiazepines impair smooth pursuit eye movements.
作者信息
Bittencourt P R, Wade P, Smith A T, Richens A
出版信息
Br J Clin Pharmacol. 1983 Feb;15(2):259-62. doi: 10.1111/j.1365-2125.1983.tb01495.x.
Abstract
Five healthy male volunteers received single oral doses of 10 mg diazepam, 20 mg temazepam and placebo, in a double-blind, randomised fashion. Smooth pursuit eye movement velocity and serum benzodiazepine concentration were measured before and after at 0.5,1,1.5,2,3,4,6,9 and 12 h after administration of the treatments. Significant decrease in smooth pursuit eye movement velocity as compared to placebo was observed between 0.5-2 h after temazepam, and between 1-2 h after diazepam. Smooth pursuit eye movement velocity was log-linearly correlated with serum temazepam and diazepam concentration. The results demonstrate the relationship between serum benzodiazepine concentration and its effect on an objective measure of oculomotor performance.
摘要
五名健康男性志愿者以双盲、随机方式接受了单次口服10毫克地西泮、20毫克替马西泮和安慰剂。在给药后0.5、1、1.5、2、3、4、6、9和12小时的前后分别测量了平稳跟踪眼球运动速度和血清苯二氮䓬浓度。与安慰剂相比，替马西泮给药后0.5至2小时以及地西泮给药后1至2小时观察到平稳跟踪眼球运动速度显著下降。平稳跟踪眼球运动速度与血清替马西泮和地西泮浓度呈对数线性相关。结果证明了血清苯二氮䓬浓度与其对眼动性能客观指标的影响之间的关系。
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