Otsuka A, Masugi F, Ogihara T, Saeki S, Koyama Y, Kumahara Y
Clin Exp Hypertens A. 1983;5(4):625-35. doi: 10.3109/10641968309081797.
The effect of 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine (HAGPC), a major component of antihypertensive polar renomedullary lipid, on the pressor responses to norepinephrine and angiotensin II was investigated in normal Wistar rats. The pressor activity of norepinephrine (1 microgram/kg of body weight (BW)) and angiotensin II (40 ng/kg BW) were markedly suppressed when these substances were injected immediately after intravenous administration of 80 nmol/kg BW of HAGPC. When HAGPC was infused continuously at a rate of 20 nmol/kg BW/min, pressor responses to bolus injection of graded doses (0.5 to 10 micrograms/kg BW) of norepinephrine were significantly lowered, but pressor responses to 10 to 200 ng/kg BW of angiotensin II were not affected. These observations suggest that HAGPC has alpha-adrenergic blocking activity and does not influence angiotensin II receptors.
在正常Wistar大鼠中，研究了抗高血压极性肾髓质脂质的主要成分1-O-十六烷基-2-O-乙酰基-sn-甘油-3-磷酸胆碱（HAGPC）对去甲肾上腺素和血管紧张素II升压反应的影响。当在静脉注射80 nmol/kg体重的HAGPC后立即注射去甲肾上腺素（1微克/千克体重（BW））和血管紧张素II（40纳克/千克体重）时，它们的升压活性明显受到抑制。当以20 nmol/kg体重/分钟的速率连续输注HAGPC时，对分级剂量（0.5至10微克/千克体重）去甲肾上腺素的推注注射的升压反应显著降低，但对10至200纳克/千克体重血管紧张素II的升压反应不受影响。这些观察结果表明，HAGPC具有α-肾上腺素能阻断活性，并且不影响血管紧张素II受体。
