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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Pennec J P, Peyraud C

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;74(2):477-80. doi: 10.1016/0742-8413(83)90135-4.

The intrinsic effects of adrenaline on the myocardium of the eel in winter were investigated in the isolated perfused eel heart. 2. Adrenaline was ineffective both on the pacemaker activity and auricular action potentials but markedly increased ventricular action potential duration, thus leading to an auriculo-ventricular desynchronisation. 3. This effect was not reversed by propranolol but was by phentolamine and was attributed to the stimulation of alpha receptors. 4. Clonidine reproduced the effect of adrenaline but also decreased the cardiac rhythm, possibly via alpha 2 adrenoceptors. 5. No direct inotropic effect was observed.

在离体灌流的鳗鱼心脏中研究了冬季肾上腺素对鳗鱼心肌的内在作用。2. 肾上腺素对起搏点活动和心房动作电位均无作用，但显著增加心室动作电位时程，从而导致房室不同步。3. 普萘洛尔不能逆转这种作用，但酚妥拉明可以，这种作用归因于α受体的刺激。4. 可乐定重现了肾上腺素的作用，但也可能通过α2肾上腺素受体降低心律。5. 未观察到直接的正性肌力作用。

Pennec J P, Peyraud C

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;74(2):477-80. doi: 10.1016/0742-8413(83)90135-4.

The intrinsic effects of adrenaline on the myocardium of the eel in winter were investigated in the isolated perfused eel heart. 2. Adrenaline was ineffective both on the pacemaker activity and auricular action potentials but markedly increased ventricular action potential duration, thus leading to an auriculo-ventricular desynchronisation. 3. This effect was not reversed by propranolol but was by phentolamine and was attributed to the stimulation of alpha receptors. 4. Clonidine reproduced the effect of adrenaline but also decreased the cardiac rhythm, possibly via alpha 2 adrenoceptors. 5. No direct inotropic effect was observed.

在离体灌流的鳗鱼心脏中研究了冬季肾上腺素对鳗鱼心肌的内在作用。2. 肾上腺素对起搏点活动和心房动作电位均无作用，但显著增加心室动作电位时程，从而导致房室不同步。3. 普萘洛尔不能逆转这种作用，但酚妥拉明可以，这种作用归因于α受体的刺激。4. 可乐定重现了肾上腺素的作用，但也可能通过α2肾上腺素受体降低心律。5. 未观察到直接的正性肌力作用。