[Correlation of dopamin- and GABA-ergic mechanisms in the depressive effect of neuroleptics on pedal self-stimulation of the ventral tegmentum of the mesencephalon].

Inhibition of self-stimulation of the ventral tegmentum in male rats with droperidol, haloperidol, trifluoroperazine and chlorpromazine is realized by dopamin- and GABA-ergic mechanisms of the emotional-positive reinforcement system. The GABA-ergic rather than dopaminergic mechanisms of the positive reinforcement systems realize the fluphenazine-induced reduction of self-stimulation of the midbrain ventral tegmentum. Analogous effects of clozapine and thioridazine are realized outside the dopamin- and GABA-ergic mechanisms of the reinforcement system.