Effect of combined GABA-ergic and dopaminergic stimulation on the action of some antiepileptic drugs in pentetrazol-induced convulsions.

Apomorphine (up to 10 mg/kg) and amantadine (up to 100 mg/kg) did not affect pentetrazol-induced convulsions in mice. One of two GABA-ergic agonists tested, baclofen (10 mg/kg), decreased seizure susceptibility (except for the clonic phase) while another, amino-oxyacetic acid (up to 20 mg/kg) had no effect. Combined treatment was most effective in the case of baclofen (5 mg/kg) and amantadine (100 mg/kg) where number of animals with tonic seizures was decreased. Dopaminergic stimulation did not modify the action of some anticonvulsants tested. However, GABA-ergic stimulation resulted in a marked potentiation of the action of carbamazepine (10 mg/kg) and acetazolamide (20 mg/kg), being less pronounced in reference to diazepam (0 . 5 mg/kg) in lefadol (20 mg/kg). On the other hand, combined treatment with GABA-ergic and dopaminergic stimulants was shown to enhance the action of carbamazepine and acetazolamide, but not in the clonic phase. The obtained results suggest effectiveness of GABA-ergic stimulation in the case of all drugs tested and the combined treatment with GABA-ergic and dopaminergic agonists in potentiating the effects of some antiepileptics.