Seethalakshmi L, Steinberger A
J Androl. 1983 Mar-Apr;4(2):131-5. doi: 10.1002/j.1939-4640.1983.tb00737.x.
The present study explored the effects of experimental bilateral cryptorchidism (of 21-, 28-, and 35-days duration) and orchidopexy (14 and 42 days) in the adult rat on the secretion of inhibin by cultures of isolated Sertoli cells. Changes in serum levels of gonadotropins, testis weight, and spermatogenesis also were assessed to verify the effectiveness of the surgical procedures. Cryptorchidy resulted in a progressive decline in testicular weight and a loss of germ cells, associated with increasing serum levels of FSH and LH. Inhibin secretion in vitro became nondetectable by 28 days after surgery. At 42 days after orchidopexy, spermatogenesis showed qualitative recovery, with a small increase in testes weight. Levels of LH in the circulation declined, but only to twice the intact control levels. However, inhibin secretion and serum FSH levels returned to nearly normal values. These results indicate that bilateral cryptorchidism severely impairs the secretion of inhibin and possibly other Sertoli cell functions which may account, at least partly, for the increase in circulating FSH levels and the arrest of spermatogenesis. The effects of cryptorchidism on these parameters can be reversed to a large degree by orchidopexy.
本研究探讨了成年大鼠实验性双侧隐睾（持续21天、28天和35天）及睾丸固定术（14天和42天）对分离的支持细胞培养物中抑制素分泌的影响。还评估了促性腺激素血清水平、睾丸重量和精子发生的变化，以验证手术操作的有效性。隐睾导致睾丸重量逐渐下降和生殖细胞丢失，同时血清促卵泡激素（FSH）和促黄体生成素（LH）水平升高。术后28天，体外抑制素分泌无法检测到。睾丸固定术后42天，精子发生出现质性恢复，睾丸重量略有增加。循环中的LH水平下降，但仅降至完整对照水平的两倍。然而，抑制素分泌和血清FSH水平恢复到几乎正常的值。这些结果表明，双侧隐睾严重损害抑制素的分泌以及可能的其他支持细胞功能，这可能至少部分解释了循环FSH水平升高和精子发生停滞的原因。隐睾对这些参数的影响可通过睾丸固定术在很大程度上得到逆转。
