Perényi A, Rihmer Z, Bánki C M
J Affect Disord. 1983 May;5(2):171-7. doi: 10.1016/0165-0327(83)90010-1.
Eighty-one patients treated for a least 3 months with lithium were examined for the presence of parkinsonian symptoms. Twenty-four patients were receiving treatment with lithium alone, 30 with lithium and 1 or more neuroleptics, and 27 with lithium and antidepressant. Twenty-four of the patients were found to be free from parkinsonian symptoms. Severe rigidity was not found. Two patients receiving neuroleptic with lithium and 6 on lithium-antidepressant combinations exhibited severe tremor. Neuroleptics administered concomitantly with lithium did not aggravate parkinsonian symptoms. The combination of lithium and an antidepressant significantly increased tremor in comparison to lithium alone.
对81名接受锂盐治疗至少3个月的患者进行了帕金森症状检查。24名患者仅接受锂盐治疗，30名患者接受锂盐与1种或多种抗精神病药物联合治疗，27名患者接受锂盐与抗抑郁药联合治疗。发现24名患者无帕金森症状。未发现严重强直。2名接受锂盐与抗精神病药物联合治疗的患者以及6名接受锂盐与抗抑郁药联合治疗的患者出现严重震颤。与锂盐同时使用抗精神病药物并未加重帕金森症状。与单独使用锂盐相比，锂盐与抗抑郁药联合使用显著增加了震颤。
