Tuladhar M D, Carless J E, Summers M P
J Pharm Pharmacol. 1983 Apr;35(4):208-14. doi: 10.1111/j.2042-7158.1983.tb02914.x.
Five different polymorphic forms of phenylbutazone were prepared and characterized by differential scanning calorimetry (D.S.C.). Rapid heating rates produced single endothermic peaks due to melting but slower heating rates resulted in interconversion of three of the polymorphs to the more stable form. Interconversion on grinding the polymorphs was also observed. From equilibrium solubility and intrinsic dissolution rates it was concluded that the dissolution process could be described by the Berthoud model. The effect of some tablet excipients on the dissolution process is briefly reported.
制备了五种不同的保泰松多晶型物，并通过差示扫描量热法（D.S.C.）对其进行了表征。快速加热速率会产生由于熔化导致的单个吸热峰，但较慢的加热速率会使三种多晶型物相互转化为更稳定的形式。还观察到研磨多晶型物时的相互转化。从平衡溶解度和固有溶解速率得出结论，溶解过程可以用伯绍德模型来描述。简要报道了一些片剂辅料对溶解过程的影响。
