Arthritis Res Ther. 2008;10(3):R71. doi: 10.1186/ar2444. Epub 2008 Jun 25.
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Rhein inhibits interleukin-1 beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappa B and AP-1 in chondrocytes cultured in hypoxia: a potential mechanism for its disease-modifying effect in osteoarthritis.