Fjalland B
J Pharm Pharmacol. 1976 Sep;28(9):683-6. doi: 10.1111/j.2042-7158.1976.tb02836.x.
Guinea-pig chopped lung tissue was used to investigate the inhibitory effect of various steroidal and non-steroidal anti-inflammatory agents, antipyretics, analgesics, local anaesthetics and psychotropic drugs on mechanically induced release of prostaglandin-like material. Low concentrations of non-steroidal anti-inflammatory agents inhibited synthesis, but other antipyretics and analgesics, and the local anaesthetics had little effect. Thymoleptics, neuroleptics and monoamine oxidase inhibitors except phenelzine exhibited weak activity. It is concluded that the method is a useful pharmacological model to study prostaglandin biosynthesis. The weak effects of the psychotropic drugs suggest that they do not exert their clinical effect by inhibiting PG biosynthesis.
用豚鼠肺组织切片研究了各种甾体和非甾体抗炎药、解热药、镇痛药、局部麻醉药及精神药物对机械诱导的类前列腺素物质释放的抑制作用。低浓度的非甾体抗炎药抑制合成，但其他解热药、镇痛药及局部麻醉药作用甚微。除苯乙肼外的抗抑郁药、抗精神病药及单胺氧化酶抑制剂表现出较弱活性。结论是该方法是研究前列腺素生物合成的一种有用的药理学模型。精神药物的微弱作用表明它们并非通过抑制前列腺素生物合成发挥临床作用。
