Antonov D V
Vopr Pitan. 1983 Mar-Apr(2):45-8.
Study of the spectrum of acid proteases of dog gastric juice secreted in response to different stimuli in health and atophan gastric ulcer has shown that gastric juice may contain up to 17 proteases as evaluated from relative electrophoretic mobility of protease fractions. In individually taken gastric juice samples, there occur 4-17 or mostly about 7-9 proteases, depending on the stimulus. During ulcer formation, the incidence pattern of proteases that are secreted in response to all the stimuli noticeably deviates from normal. However, the most demonstrable alterations occur as a result of histamine administration, manifesting in the emergence of 4 fractions undetectable in health and increased secretion of the remaining proteases. Apparently, ulcer formation is accompanied by disturbance of the mechanisms that control the secretion of proteases of gastric juice, especially after histamine administration.
对健康犬和阿托方胃溃疡犬在不同刺激下分泌的胃液酸性蛋白酶谱的研究表明，根据蛋白酶组分的相对电泳迁移率评估，胃液中可能含有多达17种蛋白酶。在单独采集的胃液样本中，根据刺激因素的不同，会出现4 - 17种蛋白酶，多数情况下约为7 - 9种。在溃疡形成过程中，对所有刺激作出反应而分泌的蛋白酶的发生模式明显偏离正常。然而，最明显的变化是在给予组胺后出现的，表现为健康犬中未检测到的4个组分的出现以及其余蛋白酶分泌的增加。显然，溃疡形成伴随着控制胃液蛋白酶分泌机制的紊乱，尤其是在给予组胺后。
