Fahn S
Adv Neurol. 1983;37:177-88.
Twenty-three children and 52 adults with torsion dystonia of various etiologies and distribution patterns of the involuntary movements were treated in an open-label study with anticholinergic medication. The dosage was build up gradually until there was either benefit or tolerable adverse effect. Trihexyphenidyl was used initially, but beginning in 1979, ethopropazine was utilized in the adult subjects. Significant benefit occurred in 61% of children and in 38% of adults.
在一项开放性研究中，对23名患有扭转性肌张力障碍（病因和不自主运动分布模式各异）的儿童以及52名成人使用抗胆碱能药物进行治疗。剂量逐渐增加，直至出现疗效或出现可耐受的不良反应。最初使用的是苯海索，但从1979年起，成人受试者改用乙丙嗪。61%的儿童和38%的成人有显著疗效。
