Kitson D L, Roberts A
Proc R Soc Lond B Biol Sci. 1983 Apr 22;218(1210):49-59. doi: 10.1098/rspb.1983.0025.
We have examined the initial innervation of the head skin in Xenopus laevis embryos which is by two classes of trigeminal mechanoreceptor with beaded 'free' nerve-endings. By recording receptive areas electrophysiologically and staining peripheral sensory neurites with horseradish peroxidase, we have shown that 'movement detector' neurites from one trigeminal ganglion do not normally cross the dorsal midline of the head to innervate areas of skin on the opposite side. However, if one trigeminal ganglion is removed before peripheral innervation starts, movement detector neurites from the intact side will now cross the midline to innervate contralateral skin. These observations suggest a specific competitive interaction between movement detector neurites during their innervation of head skin. The second class of receptor, 'rapid transient' detectors, have a different pattern of innervation, crossing the midline in both normal and operated animals.
我们研究了非洲爪蟾胚胎头部皮肤的初始神经支配，其由两类具有串珠状“游离”神经末梢的三叉神经机械感受器完成。通过电生理记录感受野并用辣根过氧化物酶对周围感觉神经纤维进行染色，我们发现来自一个三叉神经节的“运动探测器”神经纤维通常不会穿过头部的背中线去支配对侧的皮肤区域。然而，如果在周围神经支配开始之前移除一个三叉神经节，来自完整一侧的运动探测器神经纤维现在会穿过中线去支配对侧皮肤。这些观察结果表明在运动探测器神经纤维支配头部皮肤的过程中存在特定的竞争性相互作用。第二类感受器，即“快速瞬态”探测器，具有不同的神经支配模式，在正常和手术动物中都会穿过中线。
