Davies S N, Kitson D L, Roberts A
J Embryol Exp Morphol. 1982 Aug;70:215-24.
The development of the ophthalmic, maxillary and mandibular nerves has been followed in Xenopus laevis embryos from the first emergence of growth cones from the trigeminal ganglia until the establishment of functional innervation of the skin or cement gland. The course of each main nerve is highly predictable and follows pre-existing openings between blocks of other tissues. The development of the mandibulary nerve was observed most easily. Like that of the other trigeminal nerves it falls into three stages: (1) A pioneer neurite emerges and a nerve forms as other, later neurites fasciculate with this. (2) On reaching the inside surface of the cement gland the neurites separate and penetrate holes in the basal lamina. (3) The neurites grow between the cells they will innervate and form free nerve endings. The scanning EM observations have been confirmed by electrical recordings from trigeminal neurones. The role of pioneer fibres and substrate guidance are discussed.
在非洲爪蟾胚胎中，从三叉神经节最初出现生长锥开始，直至皮肤或黏腺建立功能性神经支配，我们追踪了眼神经、上颌神经和下颌神经的发育过程。每条主要神经的走行高度可预测，且沿着其他组织块之间预先存在的间隙延伸。下颌神经的发育最容易观察到。与其他三叉神经一样，它可分为三个阶段：（1）一条先驱神经突出现，随着其他后续神经突与之形成束状结构，神经得以形成。（2）到达黏腺内表面时，神经突分离并穿透基膜上的孔洞。（3）神经突在它们将要支配的细胞之间生长并形成游离神经末梢。扫描电镜观察结果已通过三叉神经元的电记录得到证实。文中还讨论了先驱纤维和底物导向的作用。
